The patients whose serum 25OHD reached optimal levels after vitamin D replacement were reevaluated with the same scales in terms of symptom severity. The study was completed with 40 patients for various reasons. SANS and SAPS were used to evaluate the severity of schizophrenia symptoms, and the Wisconsin Card Sorting Test: CV4 was used for cognitive assessment. Serum 25OHD levels of 52 schizophrenia patients were measured. This study aimed to examine the effects of vitamin D replacement on positive, negative, and cognitive symptoms of schizophrenia. However, very few studies in the literature examine the effects of 25-hydroxyvitamin D (25OHD) on schizophrenia symptoms. Vitamin D receptors are demonstrated in most brain regions that are related to schizophrenia. Vitamin D plays essential roles in the brain in the context of neuroplasticity, neurotransmitter biosynthesis, neuroprotection, and neurotransmission.
Vitamin D has recently been linked to many metabolic diseases and schizophrenia. Schizophrenia is a multifactorial disease involving interactions between genetic and environmental factors.
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